In the first stage, MSS is used to estimate the probability of an affected pregnancy. Indeed, studies have shown that the selective use of NIPT among higher risk women (contingent NIPT) is less costly than universal NIPT.Ĭontingent NIPT policies use a two-stage screening strategy. NIPT-based screening policies might be acceptable if NIPT were used in a select subset of pregnancies rather than applied universally. Universal NIPT is not cost effective when viewed from these narrower perspectives. Although the societal perspective is preferred for theoretical reasons, most decision makers actually use narrower perspectives such as governmental or payer perspective. Despite the cost, studies have shown that universal NIPT screening (i.e., replacement of MSS by NIPT) is cost effective when viewed from a societal perspective. Current list prices range from $500 to $2100 per test. NIPT can provide results as early as the 10th week of pregnancy.Īlthough NIPT is more accurate than MSS, it is also costly. Thus, NIPT provides high accuracy without the risk associated with invasive diagnostic testing (amniocentesis, chorionic villus sampling). For trisomy 21 (Down syndrome), NIPT has a sensitivity (detection rate) and specificity of approximately 99%. Clinical trial results show that NIPT is both sensitive and specific. Non-invasive prenatal testing (NIPT) is a relatively new screening method that provides greater prenatal detection of aneuploidies than conventional maternal serum screening (MSS).
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